Product Details
Atorvastatin calcium Basic information
Product Name:
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Atorvastatin calcium
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Synonyms:
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Atorvastatin Calcium Anhydrous;Calcium of atorvastatin;Atorvastatin ;Atorvastatin aMorphous;atorvastatine calciuM salt;(βR,δR)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-Methylethyl)-3-phenyl-4-[(phenylaMino)carbonyl]-1H-pyrrole-1-heptanoic Acid CalciuM Salt;Atorvastatin HeMicalciuM;Sortis
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CAS:
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134523-03-8
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MF:
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C66H68CaF2N4O10
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MW:
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1155.36
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EINECS:
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200-659-6
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Atorvastatin calcium Chemical Properties
Melting point
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176-178°C
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storage temp.
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Store at +4°C
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solubility
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DMSO: ≥10mg/mL
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form
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white powder
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Atorvastatin calcium Usage And Synthesis
Mode of action
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Atorvastatin takes effect through selectively and competitively inhibiting the hepatic enzyme HMG-CoA reductase, which is responsible for converting HMG-CoA to mevalonate in the cholesterol biosynthesis pathway. This results in a subsequent decrease in hepatic cholesterol levels. Decreased hepatic cholesterol levels stimulates upregulation of hepatic LDL-C receptors which increases hepatic uptake of LDL-C and reduces serum LDL-C concentrations.
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Chemical Properties
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White Crystalline Powder
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Uses
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The primary uses of atorvastatin is for the treatment of dyslipidemia and the prevention of cardiovascular disease.
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Atorvastatin calcium Specification
Character
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A white or almost white?crystalline powder
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Identification
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A: IR.
B: CALCIUM
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water
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3.5~5.5
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Ca %
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3.0~3.6
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Particle size
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D90≤10 µm
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Heavy Metals(ppm)
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≤20
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Impurity
(HPLC)
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Impurity E
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≤0.3%
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Impurity A
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≤0.3%
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Impurity?B
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≤0.3%
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Impurity C
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≤0.3%
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Impurity D
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≤0.1%
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Other individual unknown Impurity %
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≤0.1%
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Total impurity
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≤1.0%
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Assay %
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98.0-102.0
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http://www.jecibiochem.com/